Javan Kisaka, PhD, is an instructor at the Division of Infectious Disease. He studies molecular basis of human immunodeficiency virus (HIV), specifically latent HIV reservoir and trying to better understand mechanisms of HIV replication in macrophages and resting CD4+T cells.
Dr. Kisaka was born and raised in Kenya where he earned a Bachelor of Science degree in Chemistry and Biochemistry, at the University of Nairobi in 2006. He came to the United States in 2010 as a graduate student to pursue his PhD in Chemistry at Western Michigan University in Kalamazoo, Michigan, where he studied molecular structure and dynamics of Cu(I)- P1B-type ATPases.
He joined HIV research group of Dr. George Kyei at Washington University School of Medicine in 2016 as a postdoctoral research associate. His interests in HIV research within the field of infectious disease is on viral latency, and reservoir that prevents curing HIV infection despite availability of antiretroviral therapy (ART). His mission is to understand molecular mechanisms of how HIV persists in latently infected cells. Cellular pathways that maintain HIV reservoir are good targets for development of agents that could reverse viral latency and possibly reduce HIV reservoir. His overall goal is to identify and characterize cellular factors that can be exploited to selectively reactivate latent virus with the hope that this will enable elimination of the latent HIV reservoir
- BSC, University of Nairobi, Nairobi, Kenya (2006)
- PhD, Department of Chemistry, Western Michigan University, Kalamazoo, MI (2016)
- Postdoctoral Research Associate, Infectious Diseases, Department of Medicine, Washington University School of Medicine (2016-2021)
Xiuli Hao, Freja Lüthje, Regin Rønn, Nadezhda A. German, Fuyi Huang, Javan Kisaka, David Huffman, Hend A. Alwathnani, Yong-Guan Zhu, Christopher Rensing. A Role for Copper in Protozoan Grazing-Two Billion Years Selecting for Bacterial Copper Resistance. Mol Microbial, 2016, 102(4):628-641
Regin Rønn, Xiuli Hao, Freja Lüthje, Nadezhda A German, Xuanji Li, Fuyi Huang, Javan Kisaka, David Huffman, Hend A Alwathnani, Yong-Guan Zhu, Christopher Rensing.Bacterial Survival in Dictyostelium. Bio-protocol, 2017, 7(13)
Javan K. Kisaka, Lee Ratner, George B. Kyei. The dual-specificity kinase DYRK1A modulate the levels of cyclin L2 to control HIV replication in macrophages. J Virol, 2020,94(6): 01583-19