Jennifer A. Philips, MD, PhD
Associate Professor of Medicine and Molecular Microbiology
- BA, Biochemistry, summa cum laude: Columbia Universtiy, New York NY (1987)
- Ph.D., Biochemistry and Biophysics: University of California, San Francisco, School of Medicine, San Francisco CA (1998)
- MD: University of California, San Francisco, School of Medicine, San Francisco CA (2000)
- Internship in Internal Medicine: Brigham and Womens' Hospital, Boston MA (2002)
- Residency in Internal Medicine: Brigham and Womens' Hospital, Boston MA (2002)
- Clinical Fellow in Infecitous Diseases: Brigham and Womens' Hospital, Boston MA (2003)
- Research Fellow in Infectious Diseases, Dept of Genetics. Mentors: Norbert Perrimon & Eric Rubin: Harvard Medical School, Boston MA (2006)
Mycobacterium tuberculosis (Mtb) causes tuberculosis (TB), one of the world’s most deadly infections. Mtb has infected humans for millennia and is highly adapted to navigate the complexity of the human immune system. It has long been appreciated that Mtb subverts innate immune defenses, but our molecular understanding remains incomplete.
My laboratory is focused on gaining mechanistic insight into how Mtb alters cellular trafficking, antigen presentation, host cell metabolism and cytokine responses of macrophages and dendritic cells. In studying the host-pathogen interactions that allow Mtb to sabotage cellular functions, we hope to better understand host immunity and bacterial pathogenesis.
Ouimet M, Köster S, Sakowski E, Ramkhelawon B, van Solingen C, Oldebeken S, Karunakaran D, Portal-Celhay C, Sheedy FJ, Ray TD, Cecchini K, Zamore PD, Rayner KJ, Marcel YL, Philips JA,* Moore KJ.* Mycobacterium tuberculosis induces the miR-33 locus to reprogram autophagy and host lipid metabolism, Nat Immunol 2016: 17 , 677-686. PMCID: PMC4873392. (*co-corresponding, equal contribution)
Portal-Celhay C, Tufariello JM, Srivastava S, Mehra A, Zahra A, Bean AJ, Ernst JD, Jacobs Jr. WR*, Philips JA.* Mycobacterium tuberculosis EsxH inhibits ESCRT-dependent MHC class II antigen presentation, Nature Microbiol, 2016: 2, 16232 (*co-corresponding, equal contribution).
Köster S, Upadhyay S, Chandra P, Papavinasasundaram K, Yang G, Hassan A, Grigsby S, Mittal E, Park HS, Jones V, Hsu F, Jackson M, Sassetti C, Philips, JA. Mycobacterium tuberculosis is protected from NADPH oxidase and LC3-associated phagocytosis by the LCP protein CpsA, Proc. Natl. Acad. Sci., 2017: pii:20107792. doi: 10.1073/pnas.1707792114 (Epub ahead of print).