Jennifer A. Philips, MD, PhD
Assistant Professor of Medicine
Mycobacterium tuberculosis (Mtb) causes tuberculosis (TB), one of the world’s most deadly infections. Mtb has infected humans for millennia and is highly adapted to navigate the complexity of the human immune system. It has long been appreciated that Mtb subverts innate immune defenses, but our molecular understanding remains incomplete.
My laboratory is focused on gaining mechanistic insight into how Mtb alters cellular trafficking, antigen presentation, host cell metabolism and cytokine responses of macrophages and dendritic cells. In studying the host-pathogen interactions that allow Mtb to sabotage cellular functions, we hope to better understand host immunity and bacterial pathogenesis.