George B. Kyei, MBChB, PhD

George B. Kyei, MBChB, PhD

Associate Professor, Departments of Medicine and Molecular Microbiology

George Kyei is physician scientist whose research is centered on finding a cure for HIV. He is the principal investigator of the HIV Cure Research Infrastructure Study (H-CRIS), based at the University of Ghana, which seeks to train African scientists in HIV cure research. He operates laboratories at Washington University and the University of Ghana, shares his time between the two institutions and serves as the director of research at the University of Ghana Medical Center.

Dr. Kyei specializes in HIV basic and translational research, with a special focus on viral latency and reactivation specifically:  (i) characterization of factors that control HIV replication in macrophages, dendritic and resting T cells and (ii) identification of cellular factors and small molecules required for HIV reactivation in latently infected cell and (iii) perspectives of HIV patients on HIV cure. He is currently mentoring four postdocs and four graduate students. He has hosted students/residents from the USA, including Washington University at the University of Ghana for research and clinical rotations.

Related Links
Additional Titles
  • Recent Fellowship Program Graduate
  • Principal Investigator of the HIV Cure Research Infrastructure Study (H-CRIS), based at the University of Ghana
  • The Medical & Scientific Research Directorate, University of Ghana Medical Centre
  • Medical Degree: University of Ghana Medical School, Accra, Ghana (1998)
  • MPhil, Microbiology: University of Ghana, Legon Boundary, Accra, Ghana (2003)
  • PhD, Biomedical Sciences: University of New Mexico, Albuquerque, NM (2007)
  • Residency, Internal Medicine: Barnes-Jewish Hospital, St. Louis, MO (2010)
  • Fellowship, Infectious Diseases: Washington University School of Medicine, St. Louis, MO (2014)
Board Certifications
  • American Board of Internal Medicine
  • American Board of Internal Medicine, Subspecialty of Infectious Diseases
Selected Publications
  1. George B. Kyei, Shanshan Meng , Rashmi Ramani , Austin Niu , Chandraiah Lagisetti, Thomas R Webb , Lee Ratner. Splicing factor 3B subunit 1 interacts with HIV Tat and plays a role in viral transcription and reactivation from latency. mBio. 2018 Nov 6;9(6). pii: e01423-18.
  2. Javan K. Kisaka, Lee Ratner and George B. Kyei. The dual specificity kinase DYRK1A modulates the levels of cyclin L2 to control HIV replication in macrophages. J Virol. 2020 Feb 28;94(6):e01583-19.
  3. Bonney EY, Lamptey H, Aboagye JO, Abana C, Boateng AT, Quansah DNK, Obo-Akwa A, Ganu V, Puplampu P, Kyei GB. Unwillingness of Patients in Ghana to Interrupt Antiretroviral Therapy for HIV Cure Research. J Virus Erad. 2021 Jan 1;7(1):100027. doi: 10.1016/j.jve.2020.100027. eCollection 2021 Mar. PMID: 33437495

Bibliography – George B. Kyei