Jonathan H. Sheehan, PhD

Jonathan H. Sheehan, PhD

Associate Professor of Medicine

Jonathan Sheehan is an associate professor (research-track) in the Division of Infectious Diseases, Department of Medicine.

Dr. Sheehan specializes in personalized structural biology, with a special focus on the molecular basis of disease mechanisms. He uses computational methods to predict the 3D structures of proteins, to model protein-protein and protein-drug interactions, to predict the functional and thermodynamic effects of genetic mutations, and to investigate the structure-function relationship of proteins involved in cancer, genetic disorders, and infectious diseases.

Related Links
  • A.B. – honors in Classics: Harvard College, Cambridge, MA (1988)
  • PhD – Biochemistry with Walter Chazin: Vanderbilt University, Nashville, TN (2006)
  • Post doctoral-training with Jens Meiler: Center for Structural Biology, Vanderbilt University, Nashville, TN (2008)
Selected Publications
  1. Fallen K, Banerjee S, Sheehan J, Addison D, Lewis LM, Meiler J, Denton JS. The Kir channel immunoglobulin domain is essential for Kir1.1 (ROMK) thermodynamic stability, trafficking and gating. Channels (Austin). 2009 Jan-Feb;3(1):57-68.
  2. Grabowska MM, Elliott AD, DeGraff DJ, Anderson PD, Anumanthan G, Yamashita H, Sun Q, Friedman DB, Hachey DL, Yu X, Sheehan JH, Ahn JM, Raj GV, Piston DW, Gronostajski RM, Matusik RJ. NFI transcription factors interact with FOXA1 to regulate prostate-specific gene expression. Mol Endocrinol. 2014 Jun;28(6):949-64.
  3. Sivley RM, Sheehan JH, Kropski JA, Cogan J, Blackwell TS, Phillips JA, Bush WS, Meiler J, Capra JA. Three-dimensional spatial analysis of missense variants in RTEL1 identifies pathogenic variants in patients with Familial Interstitial Pneumonia. BMC Bioinformatics. 2018 Jan 23;19(1):18.
  4. Carnes SK, Sheehan JH, Aiken C. Inhibitors of the HIV-1 capsid, a target of opportunity. Curr Opin HIV AIDS. 2018 Jul;13(4):359-365.

Bibliography – Jonathan Sheehan