Bruce A. Rosa, PhD
Associate Professor of Medicine
- Phone: 314-273-5550
- Email: barosa@nospam.wustl.edu
Dr. Bruce A. Rosa specializes in the bioinformatics analysis of high-throughput genomic, transcriptomic, proteomic and metagenomic datasets to study infectious diseases. He works in Dr. Makedonka Mitreva’s research laboratory, primarily studying parasitic helminths, with ongoing research projects on tuberculosis, malaria and other infectious diseases.
Dr. Rosa excels at the statistical analysis of complex datasets, including single-cell transcriptomics for helminths and host species, as well as shotgun metagenomics to study the host gut microbiome. He applies advanced tools and machine learning approaches, identifying novel drug targets, effective therapeutics, vaccine candidates and diagnostics for infectious diseases. Dr. Rosa also assists with mentoring graduate students and postdoctoral researchers. He serves as Associate Editor for several journals, including PLOS Neglected Tropical Diseases.
- HBSc Biology: Lakehead University, Thunder Bay, ON, Canada (2005)
- MSc Biology: Lakehead University, Thunder Bay, ON, Canada (2007)
- PhD Biotechnology: Lakehead University, Thunder Bay, ON, Canada (2012)
- Visiting Scholar Bioinformatics: Michigan State University, East Lansing, MI (2012)
- Postdoctoral Research Associate: Washington University in St. Louis, MO (2014)
- Staff Scientist Bioinformatics: McDonnell Genome Institute, Washington University in St. Louis, MO (2019)
- Singh KS*, Bharti S*, Rosa BA*, Bigham M, Uzoechi SC, Choi YJ, Martin JC, Kemper D, Djuranovic SP, Pickering DA, Ryan R, Bracken BK, Bottazzi ME, Carnes EC, Ittiprasert W, Moyle M, Brindley PJ, Loukas A, Djuranovic S, Mitreva M. Transgenic hookworm secretes anti-tetrodotoxin human single chain antibody. Nat Commun. 2026 Jun 3;17(1). doi: 10.1038/s41467-026-73447-9. PubMed PMID: 42236698; PubMed Central PMCID: PMC13233899. *Co-first authors
- Bharti S*, Rosa BA*, Martin J, Mitreva M. Single-cell transcriptome atlas of adult male and female human hookworm Ancylostoma ceylanicum. iScience. 2025 Nov 21;28(11):113846. doi: 10.1016/j.isci.2025.113846. eCollection 2025 Nov 21. PubMed PMID: 41362773; PubMed Central PMCID: PMC12682278. *Co-first authors
- Rosa BA, Curtis K, Erdmann Gilmore P, Martin J, Zhang Q, Sprung R, Weil GJ, Townsend RR, Fischer PU, Mitreva M. Direct Proteomic Detection and Prioritization of 19 Onchocerciasis Biomarker Candidates in Humans. Mol Cell Proteomics. 2023 Jan;22(1):100454. doi: 10.1016/j.mcpro.2022.100454. Epub 2022 Nov 23. Review. PubMed PMID: 36435333; PubMed Central PMCID: PMC9792368.