Bruce A. Rosa is an assistant professor of medicine, working as part of Dr. Makedonka Mitreva’s research lab. Dr. Rosa specializes in bioinformatics analyses of high-throughput genomic, transcriptomic, proteomic and metagomic datasets to study infectious diseases. His research has focused primarily on the bioinformatic study of parasitic helminths, but also includes research on tuberculosis, malaria, HIV, and other infectious diseases.
Dr. Rosa’s experience in the statistical analysis of complex datasets (utilizing multiple types of evidence spanning treatments or species) has led to the identification differentially expressed genes, drug targets and pathways of interest for experimental verification. He also performs cross-cohort microbiome analysis, both with 16S and shotgun datasets, to identify bacterial taxa inside of the human host which are associated with parasitic infections. Dr. Rosa assists with mentoring graduate students and postdoctoral researchers in Dr. Mitreva’s lab.
- HBSc Biology: Lakehead University, Thunder Bay, ON, Canada (2005)
- MSc Biology: Lakehead University, Thunder Bay, ON, Canada (2007)
- PhD Biotechnology: Lakehead University, Thunder Bay, ON, Canada (2012)
- Visiting Scholar Bioinformatics: Michigan State University, East Lansing, MI (2012)
- Postdoctoral Research Associate: Washington University in St. Louis, MO (2014)
- Staff Scientist Bioinformatics: McDonnell Genome Institute, Washington University in St. Louis, MO (2019)
- Rosa BA, Snowden C, Martin J, Fischer K, Kupritz J, Beshah E, Supali T, Gankpala L, Fischer PU, Urban JF Jr, Mitreva M. Whipworm-Associated Intestinal Microbiome Members Consistent Across Both Human and Mouse Hosts. Front Cell Infect Microbiol. 2021;11:637570. PubMed PMID: 33777847; PubMed Central PMCID: PMC7991909.
- Rosa BA, Ahmed M, Singh DK, Choreño-Parra JA, Cole J, Jiménez-Álvarez LA, Rodríguez-Reyna TS, Singh B, Gonzalez O, Carrion R Jr, Schlesinger LS, Martin J, Zúñiga J, Mitreva M, Kaushal D, Khader SA. IFN signaling and neutrophil degranulation transcriptional signatures are induced during SARS-CoV-2 infection. Commun Biol. 2021 Mar 5;4(1):290 PubMed PMID: 33674719; PubMed Central PMCID: PMC7935909.
- Rosa BA, Choi YJ, McNulty SN, Jung H, Martin J, Agatsuma T, Sugiyama H, Le TH, Doanh PN, Maleewong W, Blair D, Brindley PJ, Fischer PU, Mitreva M. Comparative genomics and transcriptomics of 4 Paragonimus species provide insights into lung fluke parasitism and pathogenesis. Gigascience. 2020 Jul 1;9(7). PubMed PMID: 32687148; PubMed Central PMCID: PMC7370270.