Andrej Spec, MD, MSCI
Associate Professor of Medicine
- Phone: 314-454-8354
- Fax: 314-454-5392
- Email: aspec@nospam.wustl.edu
Dr. Spec’s research is in fungal infections, particularly in immunocompromised patients, including those with transplants. He serves as the Section Director of Transplant Infectious Disease. His research focuses on Cryptococcus, Histoplasma, Candida, Aspergillus, and other invasive molds. He studies the epidemiology and factors that affect outcomes in patients infected with fungi.
Dr. Spec serves as the Co-Director of our Invasive Fungal Clinic, which he founded in 2016, and is actively involved with the Mycoses Study Group (MSG), where he participates and leads multicenter studies focused on new diagnostic tests and treatments for invasive fungal infections. He is also the creator and leader of the Washington University Mycoses Group (a consortium of researchers interested in fungal infections). Dr. Spec is also a Deputy Editor of Open Forum Infectious Disease and the lead editor of Comprehensive Review of Infectious Diseases, a best-selling textbook on infectious disease.
Infectious Diseases Clinic
620 South Taylor Ave., Suite 100
St. Louis, MO 63110
- Associate Director, Infectious Diseases Clinical Research Unit (ID-CRU)
- Director, Invasive Mycoses Clinic
- Section Head of Transplant ID.
- BS, Molecular Biology, Minors in Chemistry and Biostatistics: Loyola University Chicago, Chicago, IL (2005)
- Medical Degree: University of Illinois College of Medicine, Chicago, IL (2010)
- Internal Medicine Internship: Rush University Medical Center, Chicago, IL (2011)
- Internal Medicine Residency: Rush University Medical Center, Chicago, IL (2013)
- Infectious Diseases Fellowship: Washington University School of Medicine, St. Louis MO (2016)
- Masters of Science in Clinical Investigation: Washington University School of Medicine, St. Louis MO (2017)
- American Board of Internal Medicine
- American Board of Internal Medicine, Subspecialty of Infectious Diseases
- Open Forum Infectious Diseases editorial board member (2017)
- Medical Mycology editorial board member (2017)
- IDSA Mentorship Award, Program Mentee (2014)
- Chang CC, Harrison TS, Bicanic TA, Chayakulkeeree M, Sorrell TC, Warris A, Hagen F, Spec A, Oladele R, Govender NP, Chen SC, Mody CH, Groll AH, Chen YC, Lionakis MS, Alanio A, Castañeda E, Lizarazo J, Vidal JE, Takazono T, Hoenigl M, Alffenaar JW, Gangneux JP, Soman R, Zhu LP, Bonifaz A, Jarvis JN, Day JN, Klimko N, Salmanton-García J, Jouvion G, Meya DB, Lawrence D, Rahn S, Bongomin F, McMullan BJ, Sprute R, Nyazika TK, Beardsley J, Carlesse F, Heath CH, Ayanlowo OO, Mashedi OM, Queiroz-Telles Filho F, Hosseinipour MC, Patel AK, Temfack E, Singh N, Cornely OA, Boulware DR, Lortholary O, Pappas PG, Perfect JR. Global guideline for the diagnosis and management of cryptococcosis: an initiative of the ECMM and ISHAM in cooperation with the ASM. Lancet Infect Dis. 2024 Aug;24(8):e495-e512. doi: 10.1016/S1473-3099(23)00731-4. Epub 2024 Feb 9. Erratum in: Lancet Infect Dis. 2024 Aug;24(8):e485. doi: 10.1016/S1473-3099(24)00426-2. PMID: 38346436; PMCID: PMC11526416.
- Cornely OA, Sprute R, Bassetti M, Chen SC, Groll AH, Kurzai O, Lass-Flörl C, Ostrosky-Zeichner L, Rautemaa-Richardson R, Revathi G, Santolaya ME, White PL, Alastruey-Izquierdo A, Arendrup MC, Baddley J, Barac A, Ben-Ami R, Brink AJ, Grothe JH, Guinea J, Hagen F, Hochhegger B, Hoenigl M, Husain S, Jabeen K, Jensen HE, Kanj SS, Koehler P, Lehrnbecher T, Lewis RE, Meis JF, Nguyen MH, Pana ZD, Rath PM, Reinhold I, Seidel D, Takazono T, Vinh DC, Zhang SX, Afeltra J, Al-Hatmi AMS, Arastehfar A, Arikan-Akdagli S, Bongomin F, Carlesse F, Chayakulkeeree M, Chai LYA, Chamani-Tabriz L, Chiller T, Chowdhary A, Clancy CJ, Colombo AL, Cortegiani A, Corzo Leon DE, Drgona L, Dudakova A, Farooqi J, Gago S, Ilkit M, Jenks JD, Klimko N, Krause R, Kumar A, Lagrou K, Lionakis MS, Lmimouni BE, Mansour MK, Meletiadis J, Mellinghoff SC, Mer M, Mikulska M, Montravers P, Neoh CF, Ozenci V, Pagano L, Pappas P, Patterson TF, Puerta-Alcalde P, Rahimli L, Rahn S, Roilides E, Rotstein C, Ruegamer T, Sabino R, Salmanton-García J, Schwartz IS, Segal E, Sidharthan N, Singhal T, Sinko J, Soman R, Spec A, Steinmann J, Stemler J, Taj-Aldeen SJ, Talento AF, Thompson GR 3rd, Toebben C, Villanueva-Lozano H, Wahyuningsih R, Weinbergerová B, Wiederhold N, Willinger B, Woo PCY, Zhu LP. Global guideline for the diagnosis and management of candidiasis: an initiative of the ECMM in cooperation with ISHAM and ASM. Lancet Infect Dis. 2025 May;25(5):e280-e293. doi: 10.1016/S1473-3099(24)00749-7. Epub 2025 Feb 13. Erratum in: Lancet Infect Dis. 2025 Apr;25(4):e203. doi: 10.1016/S1473-3099(25)00154-9. Erratum in: Lancet Infect Dis. 2025 May;25(5):e261. doi: 10.1016/S1473-3099(25)00252-X. Erratum in: Lancet Infect Dis. 2025 Dec;25(12):e684. doi: 10.1016/S1473-3099(25)00657-7. PMID: 39956121.
- Hoenigl M, Sprute R, Egger M, Arastehfar A, Cornely OA, Krause R, Lass-Flörl C, Prattes J, Spec A, Thompson GR 3rd, Wiederhold N, Jenks JD. The Antifungal Pipeline: Fosmanogepix, Ibrexafungerp, Olorofim, Opelconazole, and Rezafungin. Drugs. 2021 Oct;81(15):1703-1729. doi: 10.1007/s40265-021-01611-0. Epub 2021 Oct 9. PMID: 34626339; PMCID: PMC8501344.
- Thompson GR 3rd, Soriano A, Cornely OA, Kullberg BJ, Kollef M, Vazquez J, Honore PM, Bassetti M, Pullman J, Chayakulkeeree M, Poromanski I, Dignani C, Das AF, Sandison T, Pappas PG; ReSTORE trial investigators. Rezafungin versus caspofungin for treatment of candidaemia and invasive candidiasis (ReSTORE): a multicentre, double-blind, double-dummy, randomised phase 3 trial. Lancet. 2023 Jan 7;401(10370):49-59. doi: 10.1016/S0140-6736(22)02324-8. Epub 2022 Nov 25. PMID: 36442484.