Megan Tierney Baldridge, MD, PhD
Assistant Professor of Medicine
- Center for Genome Sciences & Systems Biology
- BA, Biochemistry and Cell Biology: Rice University, Houston TX (2003)
- PhD, Molecular and Human Genetics: Baylor College of Medicine, Houston TX (2009)
- MD, Medicine: Baylor College of Medicine, Houston TX (2011)
- Postdoc in Pathology & Immunology: Washington University, St. Louis, MO (2016)
The Baldridge Lab studies interactions of the intestinal commensal microbiota with viral (such as murine norovirus) and bacterial pathogens, and the regulation of these interactions by the mucosal innate immune system. The lab also explores viral evolution and phenotypic alterations in different immunological and anatomical contexts, using murine norovirus as a model.
Lee S, Wilen CB, Orvedahl A, McCune BT, Kim K, Orchard RC, Peterson ST, Nice TJ, Baldridge MT#, Virgin HW# (2017). Norovirus cell tropism is determined by combinatorial action of a viral non-structural protein and host cytokine. Cell Host & Microbe, In press. #co-corresponding
Lee S and Baldridge MT. (2017). Interferon-lambda: A potent regulator of intestinal viral infections. Frontiers in Immunology, 8:749.
Baldridge MT*, Lee S*, Brown JJ, McAllister N, Urbanek K, Dermody TS, Nice TJ, Virgin HW. (2017). Expression of Ifnlr1 on intestinal epithelial cells is critical to the antiviral effects of IFN-lambda against norovirus and reovirus. Journal of Virology, 13;91(7). *equal contribution
Josefsdottir, KS, Baldridge MT, Kadmon CS, King KY. (2017). Antibiotics impair murine hematopoiesis by depleting intestinal microbiota. Blood, 129(6):729-739.