Gary J. Weil, MD
Professor, Departments of Medicine and Molecular Microbiology
- BA: Harvard College, Boston, MA (1971)
- Medical Degree: Harvard Medical School, Boston, MA (1975)
- Residency, Internal Medicine: Yale-New Haven Hospital, New Haven, CT (1978)
- Research Associate, Laboratory of Parasitic Diseases: NIAID, Bethesda, MD (1981)
- Fellowship, Infectious Diseases: Washington University School of Medicine, St. Louis, MO (1982)
- Internal Medicine
- Infectious Disease
- Clinical Tropical Medicine and Traveler's Health, (ASTMH)
Infectious diseases, tropical medicine.
My laboratory conducts research on filarial nematode parasites that cause important tropical diseases such as lymphatic filariasis and river blindness. Our work is focused on the development and field application of improved diagnostic tests, on developing improved therapies, and on basic parasite biology. For example, we have collaborated on the development of new diagnostic tests for filariasis based on detection of parasite antigens, parasite DNA, and human antibodies to recombinant parasite antigens. Ongoing field studies are exploring the value of these newer tests for monitoring the impact of mass treatment programs on filariasis prevalence rates and transmission. Basic research in the laboratory is currently focused on studies of filarial parasite gene expression across the life cycle and in response to stresses such as drug treatment and radiation. We are also studying the role of Wolbachia (endosymbiotic bacteria) on filarial worm survival and development.
The DOLF project (funded by the Bill and Melinda Gates Foundation) supports applied field research in seven countries. This exciting project pools the talent and experience of outstanding scientists from the North and South so that they can work together toward a lofty goal, namely a world without lymphatic filariasis or onchocerciasis.