Portrait of Anne Mobley Butler, PhD, MS

Anne Mobley Butler, PhD, MS

Associate Professor of Medicine

Dr. Butler is a pharmacoepidemiologist with broad research interests in non-experimental studies, real-world data, comparative effectiveness research, and epidemiologic methods. Her research involves the application of epidemiologic study designs and analytic methods to highly detailed, clinical and administrative data captured on patients as part of routine clinical care. Her substantive work focuses on the treatment and prevention of common infections, including antibiotic and vaccine utilization, effectiveness, safety, and related outcomes. She also applies and develops epidemiological methods to identify and account for common sources of biases in non-experimental studies that use administrative data. Given that various patient populations are rarely included in clinical trials, real-world evidence generated from these studies are useful to inform decisions related to clinical practice, health policy, and quality improvement interventions. Dr. Butler has secondary appointments in the WashU Bursky School of Public Health and the WashU School of Medicine Division of Public Health Sciences.

Additional Titles
Education
  • BS – Neuroscience & Behavioral Biology: Emory University, Atlanta GA (2003)
  • MS – Epidemiology: Harvard School of Public Health (2006)
  • PhD – Epidemiology: Gillings School of Global Public Health, University of North Carolina at Chapel Hill (2014)
  • Postdoctoral Fellowship – Epidemiology: Gillings School of Global Public Health, University of North Carolina at Chapel Hill (2015-2017)
Selected Publications
  1. Estimating the effectiveness of rotavirus vaccine schedules. Butler AM, Breskin A, Sahrmann JM, Brookhart MA. Epidemiology. 2021 Jul 1;32(4):598-606. doi: 10.1097/EDE.0000000000001363.
  2. Association of Inappropriate Outpatient Pediatric Antibiotic Prescriptions With Adverse Drug Events and Health Care Expenditures. Butler AM, Brown DS, Durkin MJ, Sahrmann JM, Nickel KB, O’Neil CA, Olsen MA, Hyun DY, Zetts RM, Newland JG. JAMA Netw Open. 2022 May 2;5(5):e2214153. doi: 10.1001/jamanetworkopen.2022.14153.
  3. Comparative Effectiveness of High-Dose Versus Standard-Dose Influenza Vaccine Among Patients Receiving Maintenance Hemodialysis. Butler AM, Layton JB, Dharnidharka VR, Sahrmann JM, Seamans MJ, Weber DJ, McGrath LJ. Am J Kidney Dis. 2020 Jan;75(1):72-83. doi: 10.1053/j.ajkd.2019.05.018. Epub 2019 Aug 1. 
  4. First-Trimester Antibiotic Use for Urinary Tract Infection and Risk of Congenital Malformations. Osmundson SS, Nickel KB, Shortreed SM, Dublin S, Stwalley D, Durkin MJ, Wartko PD, Sahrmann JM, Colvin R, Butler AM. JAMA Netw Open. 2025 Jul 1;8(7):e2519544. doi: 10.1001/jamanetworkopen.2025.19544.
  5. Assessing residual bias in estimating influenza vaccine effectiveness: comparison of high-dose versus standard-dose vaccines. Butler AM, Layton JB, Krueger WS, Kshirsagar AV, McGrath LJ. Med Care. 2019 Jan;57(1):73-78. doi: 10.1097/MLR.0000000000001018. 
  6. Noninterventional studies in the COVID-19 era: methodological considerations for study design and analysis.  Butler AM, Burcu M, Christian JB, Tian F, Andersen KM, Blumentals WA, Joynt Maddox KE, Alexander GC. J Clin Epidemiol. 2023 Jan;153:91-101. doi: 10.1016/j.jclinepi.2022.11.011. Epub 2022 Nov 17. PubMed PMID: 36400263; PubMed Central PMCID: PMC9671552.

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