Jacco Boon, PhD
Professor of Medicine, Molecular Microbiology and Pathology and Immunology
- Phone: 314-286-0857
- Fax: 314-286-2784
- Email: jboon@nospam.wustl.edu
Dr. Boon is a professor of Medicine, Molecular Microbiology and Pathology and Immunology at Washington University. He specializes in basic research on RNA viruses, with a special focus on emerging virus such as influenza virus, Bourbon virus and SARS-CoV-2. His laboratory is developing animal models for SARS-CoV-2 and Bourbon virus that are used to evaluate the efficacy of antiviral countermeasures against these viruses. Dr. Boon is also interested in understanding genome reassortment of influenza viruses, which is an important for the generation of pandemic viruses. The laboratory has developed the Syrian hamster COVID-19 animal model for SARS-CoV-2 and has access to dedicated biosafety level 3 laboratories.
He is currently mentoring four post-doctoral fellows and one graduate student. Dr. Boon was also a mentor for Global Health Mentoring Program aimed to prepare young scientists for a career in Global Health. Previously, he has mentored a post-doctoral fellow and five undergraduate students. He successfully graduated two graduate students, and served on more than 10 qualifying committees and thirty thesis committees.
- Masters Degree in Medical Biology: University of Amsterdam, The Netherlands (1997)
- Graduate Thesis w/ Prof. ADME Osterhaus: Erasmus Medical Center, Rotterdam, The Netherlands (2003)
- Post-doctoral Fellow: Erasmus Medical Center, Rotterdam, The Netherlands (2005)
- Post-doctoral Fellow: St Jude Children’s Research Hospital, Memphis, TN (2011)
- Reed Trende, Tamarand L. Darling, Tianyu Gan, David Wang, and Adrianus C. M. Boon. Barcoded SARS-CoV-2 viruses define the impact of duration and route of exposure on the transmission bottleneck in a hamster model. Science Advances. 15 Jan 2025. Vol 11, Issue 3. DOI: 10.1126/sciadv.ads2927
- Defining a highly conserved B cell epitope in the receptor binding motif of SARS-CoV-2 spike glycoprotein.Malladi SK, Jaiswal D, Ying B, Alsoussi WB, Darling TL, Dadonaite B, Civljak A, Horvath SC, Zhou JQ, Kim W, Turner JS, Schmitz AJ, Han F, Scheaffer SM, Farnsworth CW, Nachbagauer R, Nestorova B, Chalkias S, Klebert MK, Edwards DK, Paris R, Strnad BS, Middleton WD, O’Halloran JA, Presti RM, Bloom JD, Boon ACM, Diamond MS, Bajic G, Ellebedy AH.bioRxiv [Preprint]. 2024 Dec 9:2024.12.06.625234. doi: 10.1101/2024.12.06.625234.PMID: 39713327
- Evidence of Human Bourbon Virus Infections, North Carolina, USA.Zychowski DL, Bamunuarachchi G, Commins SP, Boyce RM, Boon ACM.Emerg Infect Dis. 2024 Nov;30(11):2396-2399. doi: 10.3201/eid3011.240499. Epub 2024 Oct 9.PMID: 39387510 Immunogenicity and efficacy of XBB.1.5 rS vaccine against the EG.5.1 variant of SARS-CoV-2 in Syrian hamsters.Soudani N, Bricker TL, Darling T, Seehra K, Patel N, Guebre-Xabier M, Smith G, Davis-Gardner M, Suthar MS, Ellebedy AH, Boon ACM.J Virol. 2024 Oct 22;98(10):e0052824. doi: 10.1128/jvi.00528-24. Epub 2024 Sep 4.PMID: 39230305
- Mucosal immunization with ChAd-SARS-CoV-2-S prevents sequential transmission of SARS-CoV-2 to unvaccinated hamsters.Darling TL, Harastani HH, Joshi A, Bricker TL, Soudani N, Seehra K, Hassan AO, Diamond MS, Boon ACM.Sci Adv. 2024 Aug 2;10(31):eadp1290. doi: 10.1126/sciadv.adp1290. Epub 2024 Jul 31.PMID: 39083604