Hilary Babcock, MD, MPH and Jennie Kwon, DO, MSCI are co-authors of MMRW early release of reports on COVID-19 Hospitalizations and Vaccine Effectiveness

Real-world evaluations have demonstrated high effectiveness of vaccines against COVID-19–associated hospitalizations (1–4) measured shortly after vaccination; longer follow-up is needed to assess durability of protection. In an evaluation at 21 hospitals in 18 states, the duration of mRNA vaccine (Pfizer-BioNTech or Moderna) effectiveness (VE) against COVID-19–associated hospitalizations was assessed among adults aged ≥18 years. Among 3,089 hospitalized adults (including 1,194 COVID-19 case-patients and 1,895 non–COVID-19 control-patients), the median age was 59 years, 48.7% were female, and 21.1% had an immunocompromising condition.